One hundred and seventy-two patients were enrolled in the primary analysis median dose was 133.3 mg/kg and 46 (37.8%) had concentration above 100-line in the first test. Subgroups were created based on ingested dose, rate of concentration above 100-line were investigated.
Multiple linear regression was performed to determine the effect of ingested dose on paracetamol concentration. The inclusion criteria were single acute paracetamol overdose, presentation within 15 h, and age ≥ 14 years. Methodsĭata were retrieved from two emergency medical centers retrospectively, between 20. This study aimed to examine whether using an reported dose is safe to predict concentration above the 100-line. Emergency medical centers in some developing countries lack the resources for timely reporting of paracetamol concentrations, hence treatment depends on reported dose. The United Kingdom guideline for acute paracetamol overdose has recommended the use of ‘100-treatment line’.
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